Synergistic Effect of Pericarp of Mangosteen and Propolis from Stingless Bee Extracts on Nitric Oxide Scavenging Activity
Imron Meechai et.al.
Program in Chemistry, Faculty of Science Technology and Agriculture, Yala Rajabhat University, 95000, Thailand
Vol. 7 No. 1 (2023): Journal of Tropical Pharmacy and Chemistry
Key research conclusions:
In this study, the researchers investigated the potential benefits of using extracts from the mangosteen pericarp and stingless bee propolis to remove nitric oxide, which can be harmful in certain circumstances. Nitric oxide is a signalling molecule that plays a role in several physiological processes, but in excess amounts, it can lead to inflammation and tissue damage.
Nitric oxide contamination can occur in various ways, depending on the context. In industrial settings, nitric oxide can be released into the environment as a by-product of combustion processes, such as those involved in power generation, transportation, and manufacturing. Industrial activities such as mining, welding, and chemical production can also release nitric oxide and other harmful gases into the air and water.
In the human body, nitric oxide is produced naturally as a signalling molecule by various types of cells, including endothelial cells, immune cells, and neurons. However, excessive production of nitric oxide due to inflammation, infection, or other factors can lead to tissue damage and contribute to the development of various diseases.
In some cases, nitric oxide contamination can also occur as a result of exposure to certain chemicals or toxins, such as pesticides or heavy metals. These substances can interfere with the body’s ability to regulate nitric oxide levels and contribute to the development of health problems.
To obtain the extracts, the researchers used ethanol extraction methods and identified the presence of beneficial chemicals such as xanthones and flavonoids. These compounds have been previously found to possess anti-inflammatory, antioxidant, and anticancer properties.
When the researchers tested the extracts from mangosteen pericarp and stingless bee propolis separately, they found that each had a significant effect on reducing nitric oxide levels. However, when tested together, the extracts had a synergistic effect, meaning that they worked even better than when tested individually.
This study suggests that using a combination of these extracts could be a promising strategy for developing drugs to treat inflammation and related disorders in the future. By targeting nitric oxide levels, the extracts may help alleviate inflammation and prevent tissue damage associated with chronic inflammation. However, more research is needed to fully understand the potential benefits and mechanisms of action of these extracts, as well as their safety and efficacy for human use.
